2009, discovery of a brand new phenotype for germs in slim nanofluidic slits; and initially detection of community protein buildings together DNA applying solid-condition nanopores
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Again in 1991, Sumio Iijima of your NEC Corporation had reported the synthesis of carbon nanotubes. Band structure calculations suggested that these nanotubes could exhibit metallic band conduction. This would be a significant advantage more than the conducting polymers we had explored, which were, in fact, disordered semiconductors providing merely variable-variety hopping conductivity.
2007, initially genuine-time detection of strand Trade in homologous recombination by RecA; discovery of the minimal persistence duration of finishes of microtubules; and settled the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is often a hugely flexible protein composition; and 1st detection of DNA knots making use of nanopores
Instance (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim with the pore is highlighted in crimson, and a 3D rendering with the motion of the DNA rod is shown.
Considering that 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling studies of nucleosomes and DNA maintenance proteins to DNA translocation by nanopores. Just lately his analysis has focused on finding out cell division with bacteria on chip, though his supreme curiosity is during the course of acknowledging artificial cells.
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‘The fantastically subtle way during which components in nature functionality under no circumstances ceases to amaze me. If we fix the puzzle of how existence came into remaining, I be expecting that my amazement with the complexity of creation may have increased and with it my awe with the greatness with the Creator.’
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with research from reports of DNA loop extrusion and supercoiling to DNA translocation by means of nanopores. Extra just lately his study has centered on studying chromatin framework and cell division with micro organism on chip, whilst he is likewise trying to ultimately Create artificial cells from the bottom up.
Cees Dekker is Distinguished University Professor at TU Delft. Skilled ceesdekker.net for a physicist, he pioneered nanotechnology with quite a few discoveries on carbon nanotubes during the nineteen nineties. Due to the fact 2000, he moved to solitary-molecule biophysics and nanobiology. His recent investigation focuses on (i) nanopores for protein sequencing; (ii) chromosome construction, in particular SMC motor protein; and (iii) developing a dwelling artificial cell from lifeless molecules. Dekker is definitely an elected member from the KNAW and fellow to the APS and the IOP.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart design in 2005. (nl)